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Studies on biomedical application of Nanoparticles-based systems for diagnosis and therapy Nanoparticles (NPs) can be used in biomedical applications, where they facilitate laboratory diagnostics, or in medical drug targeting. They are used for in vivo applications such as tumor therapy, cardiovascular disease, or contrast agent for magnetic resonance imaging (MRI). Although NPs are currently widely used in biomedical technology, there is a serious lack of information concerning their implication in human health. For most NPs no toxicity data are available. The major toxicological concern is the fact that some NPs cross cell membranes and are redox active. The studies of the perturbation induced by NPs on basic cellular functions is crucial in order to disclose the early events that could establish a potential hazard to health. The aim of the project is to critically investigate the biophysical, biological and molecular aspects of NPs-cell/tissue interaction, and their biological fate and transport in the human body compartments. |
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